Aging, Beta Blockers, and Thermoregulatory Responses
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Texas Southwestern Medical Center
About this trial
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
Eligibility criteria
Qualifiers
Healthy and free of any significant medical problems
Normal resting electrocardiogram
65+ years of age
Controlled cholesterol of less than 200 mg/dl
Disqualifiers
Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
Serious abnormalities detected on routine screening
Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
Current smokers, as well as individuals who regularly smoked within the past 3 years
Trial design
Treatments tested in this trial
- Ambient Heat
Treatment groups
22 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Source ClinicalTrials.gov