Antihistamine for Prevention of HTR After Blood Primed CPB
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age1-7
SponsorKasr El Aini Hospital
About this trial
This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.
Eligibility criteria
Qualifiers
Acyanotic congenital heart disease.
Age :1 -7 years.
Genre: both.
Disqualifiers
Redo patient.
History of allergy to antihistamines.
Bleeding disorders with INR > 1.5 and/or platelets < 50,000.
Emergency procedure.
Trial design
Treatments tested in this trial
- Antihestamine
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Kasr El Aini Hospital
Lead sponsor
Misr University for Science and Technology
Collaborator
Source ClinicalTrials.gov