This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).
Diagnosis of Turner Syndrome and Primary Ovarian Insufficiency.
Prescribed adult dosing* of transdermal or oral estradiol for estrogen replacement therapy.
Have achieved menarche.
Disclosure of sexual activity and desire for contraception.
Having a levonorgestrel-releasing intrauterine device or etonogestrel arm implant in place.
Having received depot medroxyprogesterone within one year prior to study recruitment.
Non-English or non-Spanish speaking.