Bone, Exercise, Alendronate, and Caloric Restriction

ConditionBone Loss

Trial statusRecruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age60+

SponsorWake Forest University Health Sciences

About this trial

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.

Eligibility criteria

Qualifiers

Community-dwelling

BMI>30 kg/m² or BMI 25.0 to <30 kg/m² plus one risk factor

Currently receiving routine (annual) dental care

Pre-existing low bone mass (T-score ≤-1.1 to >-2.5 at the hip, femoral neck, or lumbar spine (L1-L4))

Disqualifiers

Weight greater than 450 lbs (DXA limit)

Resides with someone who is currently participating in BEACON

Dependent on quad cane or walker; inability to walk independently

History of mild cognitive impairment or dementia or evidence of cognitive impairment ((score <20) on Montreal Cognitive Assessment (MoCA))

Trial design

Treatments tested in this trial

Bisphosphonate
Resistance Training/Bone-Loading Exercise
Placebo

Treatment groups

900 Participants

are divided into 4 treatment groups

Sponsors and collaborators

Wake Forest University Health Sciences

Lead sponsor

National Institute on Aging (NIA)

Collaborator

Source ClinicalTrials.gov