About this trial
This study evaluates whether calcium dobesilate, a venoactive drug, improves recovery after radiofrequency ablation (RFA) for varicose veins. Patients with great saphenous vein insufficiency undergoing RFA will be randomly assigned to receive either calcium dobesilate (500 mg twice daily) or standard care alone. The treatment starts 7 days before the procedure and continues for 30 days after. The primary outcome is postoperative pain at day 7. Secondary outcomes include pain at days 14 and 30, quality of life, ecchymosis, and return to daily activities.
Eligibility criteria
Qualifiers
Age 18-70 years
Symptomatic primary varicose veins (CEAP classification C2-C4)
Great saphenous vein insufficiency confirmed by duplex ultrasound (reflux >0.5 seconds)
Great saphenous vein diameter 5-12 mm
Disqualifiers
History of deep vein thrombosis
Peripheral arterial disease (ABI <0.9)
Active venous ulcer (CEAP C6)
Pregnancy or breastfeeding
Trial design
Treatments tested in this trial
- calcium dobesilate
Treatment groups
Sponsors and collaborators
Oguz Arslanturk
Lead sponsor
Bulent Ecevit University
Sponsor institution