CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorOttawa Heart Institute Research Corporation

About this trial

The investigators are interested in determining if there is a meaningful benefit from the use of medications purported to increase the pumping function of the heart (i.e. inotropes) among critically ill patients admitted to the Cardiac Intensive Care Unit (CICU). To do this, the investigators will conduct a multi-centre, double blind, randomized control trial with patients who are deemed to require these medications by their treating physician to one of the two most commonly used agents in Canada (Milrinone or Dobutamine) or placebo. Each patient will be closely monitored by their healthcare team. The dose of medication will be adjusted according to each patients' clinical status. After 12 hours, the participants will move to open label treatment and any continued use of inotropes will be at the discretion of their treating physician.

Eligibility criteria

Qualifiers

Adult patients ≥ 18 years of age admitted to an intensive care unit

SCAI class C or D cardiogenic shock

Disqualifiers

Unwilling or unable to obtain informed consent by the participant or substitute decision maker

Patients who are currently pregnant or breast-feeding

Patients presenting with an out-of-hospital cardiac arrest (OHCA)

Administration of milrinone or dobutamine in the 24 hours preceding anticipated randomization

Trial design

Treatments tested in this trial

  • Dobutamine
  • Milrinone
  • Normal Saline

Treatment groups

346 Participants
are divided into 2 treatment groups