Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for all study visits
Aged 18 years and older
In good health based on self-reported medical conditions via an online survey
Known allergic reactions to components of the study vaccine
Known latex allergy
History of severe reactions following previous immunization with licensed or unlicensed influenza virus vaccines
History of GBS within 6 weeks of receipt of a previous influenza vaccine
University of Pennsylvania
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator
Stanford University
Collaborator
The Scripps Research Institute
Collaborator