The aim of this trial is to test whether postoperative antibiotics targeted towards bacteria in the urine can reduce the risk of infection after surgical removal of the bladder (cystectomy) compared to a standardised antibiotic prophylaxis.
Participants undergoing cystectomy will be randomly assigned to postoperatively receive (A) a standardised orally administered antibiotic prophylaxis currently given at Rigshospitalet, Copenhagen or (B) a conventional orally administered antibiotic prophylaxis targeting bacteria found in the urine postoperatively.
The investigators' hypothesis is that the targeted prophylactic antibiotic strategy will reduce the number of infection-related readmissions within 90 days of surgery compared to the standardised prophylaxis.
Age at surgery ≥ 18 years
Ability to understand and sign an informed consent
Malignant or benign indication for undergoing cystectomy
Planned ileal conduit as urinary diversion
Previous severe allergic reaction to antimicrobial treatment
Long-term prophylactic antibiotic treatment which is expected to be continued after the cystectomy