Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age20+
SponsorChiang Mai University
About this trial
The goal of this clinical trial is to evaluate the efficacy of colistin compared with colistin plus fosfomycin against carbapenem-resistant Acinetobacter baumanii infection in Thailand. The main questions it aims to answer the following main questions:
1. Which group has better clinical response at end of treatment 2. Which group has better clinical response at 72 hours and micrological cure at 72 hours and at end of treatment
Eligibility criteria
Qualifiers
≥ 20 years old patients who have CRAB infections (pneumonia, urinary tract infection, skin and soft tissue infection, bloodstream infection)
Able to provide informed consent or having a legal proxy who can provide informed consent in case the subject is unable to provide consent on his own
Disqualifiers
Minimum inhibitory concentration (MIC) of colistin > 2 mg/L
Complicated infection with inadequate source controlled
Intracranial infection
Infective endocarditis
Trial design
Treatments tested in this trial
- Colistin Sodium Methanesulfonate
- Colistin Sodium Methanesulfonate plus Fosfomycin
Treatment groups
188 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov