Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorIntermountain Health Care, Inc.

About this trial

The purpose of this study is to see if, in selected patients with a serious bacterial infection of the bloodstream, treating the bacterial infection with a combination of antibiotics is more effective than treating the infection with a single antibiotic. Participants must have blood cultures which are positive for a certain type of bacteria.

Eligibility criteria

Qualifiers

Age ≥18 years

Alive and admitted to an Intermountain Health (IH) hospital acute care unit at enrollment

on or during the index admission to an IH hospital, or

in an ambulatory setting (laboratory, clinic or emergency department) within 48 hours of the index admission, or

Disqualifiers

Patient requests that patient health data not be included in the analysis

Trial design

Treatments tested in this trial

  • Antibiotic Monotherapy (AM) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB)
  • Antibiotic Monotherapy (AM) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)
  • Combination Antibiotic Therapy (CAT) for patients with methicillin-sensitive S. aureus bacteremia (MSSAB)
  • Combination Antibiotic Therapy (CAT) for patients with methicillin-resistant S. aureus bacteremia (MRSAB)

Treatment groups

2,096 Participants
are divided into 2 treatment groups