Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and Fentanyl

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age20-60
SponsorNashwa Ahmed

About this trial

Spinal anesthesia is the most widely employed procedure for lower limb orthopedic operations, as it is very cost-effective and simple to apply. These advantages could be restricted because presently existing local anesthetic drugs had relatively short length of action. (1) Spinal anesthesia with 0.5% heavy bupivacaine (hyperbaric) is a common technique, still there was burden of its short duration of action. To overcome this issue, there was a continuous search for an ideal adjuvant.(2) Adjuvants were mostly added to local anesthetic drugs to increase their effectiveness, speedy onset, increase the period of the block, and reduce the local anesthetics dosage, thus reduction their adverse effects.(3) Such adjuvants had been beneficial in extension of analgesia along with initiation of movement though their related side effects.(4)

Eligibility criteria

Qualifiers

The patient aged range from 20 to 60 years

ASA 1 and 2

Patient prepared for elective lower limb orthopaedic surgeries.

Height 150-180 cm.

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Dexmedetomidine
  • fentanyl

Treatment groups

40 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Nashwa Ahmed

Lead sponsor

Port Said University hospital

Sponsor institution