Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl as Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-55
SponsorAssiut University

About this trial

Lower abdominal surgeries often result in severe pain, which in turn can cause rapid and shallow breathing, retention of secretions and poor patient compliance. Justifiably, apart from the fear for the surgery outcome, patients are concerned mainly with postoperative pain. If treated inadequately, acute pain can have serious consequences for patient health mainly with postoperative complications, prolonged recovery and increased length of hospital stay. Higher levels of postoperative pain and pain distress are associated with increased morbidity, poorer functional recovery, and reduced quality of life.

Aim of the study To compare the duration, quality of analgesia, and side effects between intrathecal Magnesium sulfate, neostigmine and fentanyl as adjuvant for bubivacaine as postoperative analgesia in lower abdominal surgeries

Eligibility criteria

Qualifiers

• the American Society of Anesthesiologists (ASA) classification I-II

Age >18 up to 55 years old

Both sex

Patients who will undergo lower abdominal surgeries

Disqualifiers

• Patients' refusal.

Patients with morbid obesity, cardiac diseases, hepatic diseases, renal diseases, diabetes mellitus with polyneuritis.

Patients who were in risk-scoring groups American Society of Anesthesia III-IV.

Hypertensive patients receiving therapy with adrenergic receptor antagonist, calcium channel blocker and/or angiotensin converting enzyme inhibitor.

Trial design

Treatments tested in this trial

  • Magnesium Sulfate and Bupivacaine 0.125%
  • bupivacaine and Neostigmine
  • fentanyl and bupivacaine

Treatment groups

66 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators