Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age40+
SponsorCopenhagen Respiratory Research
About this trial
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days.
Participants will randomized to receive treatment with either hydrocortisone or prednisolone.
Eligibility criteria
Qualifiers
Age ≥40 years
Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44
Disqualifiers
All diagnoses that would merit treatment with a specific corticosteroid
Pregnant or breastfeeding women
Active tuberculosis or invasive fungal infection
Trial design
Treatments tested in this trial
- Methylprednisolone (drug)
- Hydrocortisone
Treatment groups
2,000 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov