This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic stroke patients with large vessel occlusion in the anterior circulation.
Age ≥18 years
Presenting with symptoms of acute ischemic stroke
CTA or MRA confirmed occlusion of the anterior circulation (intracranial carotid artery or M1, M2 segment of the middle cerebral artery)
Randomization finished within 24 hours of symptom onset or time last know well
Pregnant or lactating women
Known allergy to contrast agents or nitinol devices
Known allergy to midazolam or other benzodiazepines
Known allergy to dexmedetomidine or its components