Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
ConditionFluid Overload
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorMorten H. Bestle
About this trial
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.
Eligibility criteria
Qualifiers
Acute admission to the intensive care unit.
Age ≥ 18 years of age
Fluid overload ≥ 5% of ideal body weight. If possible, all fluids administered before admission to the intensive care unit are to be included in the calculation of cumulative fluid balance.
Clinical stable (minimum criteria: MAP > 50 mmHg and maximum infusion of 20 microgram/kg/minute of noradrenaline and lactate < 4.0 mmol/L)
Disqualifiers
Known allergy to furosemide or sulphonamides.
Known pre-hospitalization advanced chronic kidney disease (eGFR < 30 mL/minute/1.73 m² or chronic RRT).
Ongoing renal replacement therapy.
Anuria > 6 hours.
Trial design
Treatments tested in this trial
- Furosemide
- Isotonic saline
Treatment groups
1,000 Participants
are divided into 2 treatment groupsSponsors and collaborators
Morten H. Bestle
Lead sponsor
Nordsjaellands Hospital
Sponsor institution
University of Copenhagen
Collaborator
Copenhagen Trial Unit, Center for Clinical Intervention Research
Collaborator
Centre for Research in Intensive Care (CRIC)
Collaborator
Source ClinicalTrials.gov