Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.
Patients undergoing elective general anesthesia for unilateral knee joint surgery.
Patients who provide informed consent.
Aged between 18 and 65 years old, regardless of gender.
American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ
Femoral neuropathy.
Coagulation dysfunction.
Allergy to local anesthetics.
Infection at the puncture site.