Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorPeking University First Hospital
About this trial
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia improved postoperative analgesia and subjective sleep quality in patients after scoliosis correction surgery. The purpose of this trial is to test the hypothesis that dexmedetomidine-esketamine combination used as a supplement during general anesthesia and postoperative intravenous analgesia may reduce sleep disturbances in adult after major noncardiac surgery.
Eligibility criteria
Qualifiers
Aged ≥18 years.
Scheduled for major noncardiac surgery (≥60 minutes) under general anesthesia with an expected end of surgery no later than 18:00 pm.
Required patient-controlled intravenous analgesia after surgery.
Disqualifiers
Emergency surgery, transurethral surgery, organ transplantation.
Pregnant or lactating women.
Patients who need hypnotics for sleep disturbance or antidepressants for depression prior to surgery.
History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.
Trial design
Treatments tested in this trial
- Dexmedetomidine-esketamine combination
- Placebo
Treatment groups
476 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov