Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
ConditionLyme Borreliosis, Nervous System
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorRadboud University Medical Center
About this trial
The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are:
Does addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis.
Participants will:
Take hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.
Eligibility criteria
Qualifiers
Patients who are 18 years of age or older
Patients with probable or possible signs and symptoms attributed to Lyme borreliosis
Patients with probable or possible post Lyme treatment Lyme borreliosis syndrome (PTLBS)
Males or non-pregnant females (who must agree to use barrier methods of contraception during the study therapy period, women of childbearing age must have a negative urine pregnancy or serum test at baseline).
Disqualifiers
Known contra-indication for used study medication.
Women who are pregnant or lactating
Trial design
Treatments tested in this trial
- Hydroxychloroquin
- Placebo
- Doxycycline
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Radboud University Medical Center
Lead sponsor
Ministerie van Volksgezondheid, Welzijn en Sport
Collaborator
Source ClinicalTrials.gov