Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorVZW Cardiovascular Research Center Aalst
About this trial
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
The main questions it aims to answer are:
* Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients?
Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation.
Participants will:
* Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.
Eligibility criteria
Qualifiers
Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR >0.80 and no diameter stenosis >50%
Normal, TIMI 3 flow at angiography
Stable haemodynamics
Disqualifiers
Clinical signs or symptoms of congestive heart failure
Severe valvular heart disease requiring either surgical or percutaneous intervention
History of coronary artery bypass grafting
Tortuous coronary anatomy in which wire manipulation could be complex
Trial design
Treatments tested in this trial
- Saline (NaCl)
- Metoprolol Tartrate
Treatment groups
46 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov