Effect of Blood Flow by Botulinum Toxin Injection for Severe Peripheral Artery Occlusive Disease
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age20+
SponsorYonsei University
About this trial
The purpose of this study is to investigate the effect of subcutaneous injection of botulinum toxin A on wound healing caused by lower extremity ischemia.
Eligibility criteria
Qualifiers
Age ≥ 20 years old
Patients who have a lower extremity wound among those who have been diagnosed with moderate or severe lower extremity ischemia
Patients who are unable to perform additional procedures (angioplasty, etc.) by performing peripheral vascular examination and CT angiography
Wound size ≥ 1x1cm2 to ≤ 3x3cm2
Disqualifiers
Patients with diseases that can affect neuromuscular function, such as myasthenia gravis, Eaton-Lamberton syndrome, amyotrophic lateral sclerosis, and motor neuropathy
Within 4 weeks before screening, aminoglycoside antibiotics, curare-like agents, or drugs that inhibit neuromuscular function (muscle relaxants, anticholinergics, benzodiazepines, benzamides, tetracyclines, Rinco Those who have taken mycin antibiotics, etc.)
Those taking aspirin, NSAIDs or anticoagulants within 7 days before screening
Those who have received botulinum toxin preparations within 3 months before screening
Trial design
Treatments tested in this trial
- Botulinum toxin A
Treatment groups
15 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov