The investigators hope to learn if low sodium oxybate (LXB) is an effective treatment for symptoms of idiopathic hypersomnia (IH) and postural tachycardia syndrome (POTS). Previous research has shown that patients with IH also report having symptoms associated with POTS. The researchers have observed that in patients with both IH and POTS, when patients' sleep quality improves, so do their POTS symptoms. The goal of this study is to test this in a controlled way by using LXB as a treatment for both IH and POTS in patients that have been diagnosed with both conditions.
Age ≥ 18 years
English speaking and capable of signing the informed consent form and comply with the protocol requirements
Diagnosis of IH based on ICSD-3 criteria
Diagnosis of POTS based on the 2011 Consensus Criteria
Hypersomnia due to another medical, behavioral, sleep, or psychiatric disorder
Evidence of untreated or inadequately treated sleep disordered breathing, defined as AHI ≥ 10
History of bipolar or psychotic disorders, major depressive episode, or current suicidal risk
Pregnant or lactating or intends to become pregnant during the study