Effect of Nitropaste in Chest Masculinizing Surgery

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age18+
SponsorUniversity of Virginia

About this trial

Nitropaste is a topical agent that contains 2% nitroglycerin. It is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature. While its main indication is for angina pectoris, there have been many studies showing improved survival of axial and random pattern flaps. Furthermore, recent clinical studies highlight significantly decreased mastectomy flap wound complication and need for sharp debridement. Nitropaste has low rates of side effects and is very well tolerated in general. To this date, there's no study that investigates its utility on patients who are undergoing chest masculinizing surgery. The purpose of this study is to investigate the potential utility of nitropaste in reducing rates of wound complications in patients undergoing chest masculinizing surgery.

Eligibility criteria

Qualifiers

Any adult (18 or older) patients of any gender identity who are undergoing chest masculinizing surgery with double incision and free nipple grafting.

Disqualifiers

Minor patients (younger than 18)

Anyone who's not getting free nipple grafting

Anyone who's not utilizing double incision pattern

Prisoners, anyone who is allergic to nitropaste

Trial design

Treatments tested in this trial

  • Nitro-Bid 2 % Topical Ointment

Treatment groups

256 Participants
are divided into 2 treatment groups

Sponsors and collaborators