This trial was a 1:1 (active:placebo) randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of prednisone and aspirin for the in vitro fertilization and embryo transfer outcome among patients with thyroid autoimmunity.
TPOAb>34IU/ml and/or TgAb>115IU/ml
≥5 follicles with average diameter lager than 14 mm at trigger day
≥5 oocytes retrieved
for frozen embryo transfer, at least 2 cleavage stage embryos, among which at least one morphologically good quality embryo, or at least 1 morphologically good quality embryo in blastocyst stage
hyperthyroidism
intrauterine adhesion
with endometrium thickness less than 6mm
uterine malformation
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead sponsor
Ningbo Women & Children's Hospital
Collaborator
Jinhua People's Hospital
Collaborator
Jiaxing Maternity and Child Health Care Hospital
Collaborator