Rapid sequence intubation is commonly performed in the emergency department to secure the airway of critically ill patients. However, blood pressure may decrease during or shortly after intubation because of the patient's underlying illness, the effects of induction medications, and the transition to positive-pressure ventilation. This complication is known as peri-intubation hypotension and is associated with worse clinical outcomes.
This study will evaluate whether a preemptive low dose of intravenous adrenaline, also known as epinephrine, can reduce peri-intubation hypotension in adult emergency department patients undergoing rapid sequence intubation. Participants will be randomly assigned to receive either 10 mcg of intravenous adrenaline or 1 mL of 0.9% sodium chloride placebo immediately before induction. The study will compare hemodynamic changes, vasopressor requirements, safety outcomes, and mortality between the two groups.
Adult patients aged 18 years or older
Patients in the emergency department for whom the treating physician has made a clinical decision to perform rapid sequence intubation
Patients who are hypotensive, defined as systolic blood pressure less than 90 mmHg or mean arterial pressure less than 65 mmHg, or who are considered to be at significant risk of hypotension during rapid sequence intubation
Written informed consent obtained from the patient or from a legally authorized representative when the patient lacks decision-making capacity
Pregnancy
Known allergy to adrenaline
Known contraindication to adrenaline administration
Withdrawal of consent by the patient or legally authorized representative after enrollment
Marmara University Pendik Training and Research Hospital
Lead sponsor
Marmara University
Sponsor institution