Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient

ConditionDental Caries
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age4-12
SponsorKing Abdulaziz University

About this trial

This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries.

The main questions it aims to answer are:

What is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants

Participants/Parent will:

The parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)

Eligibility criteria

Qualifiers

Healthy patients.

Patients within 4-10 years of age.

The presence of at least one deciduous tooth with a caries lesion that is directly accessible (cavitates)

Disqualifiers

Presentation of irreversible pulpititis or necrosis• The extensive lesion was restored.

The surface of the lesion was hard and smooth.

Children with inherited or systemic conditions.

Children with a substantial medication history or those who have taken antibiotics within the previous three months.

Trial design

Treatments tested in this trial

  • Silver diamine Fluoride 38%
  • Silver diamine fluoride- potassium iodide

Treatment groups

50 Participants
are divided into 2 treatment groups

Sponsors and collaborators

King Abdulaziz University

Lead sponsor

King Fahd Medical Research Centre

Collaborator