This study aims to investigate how the timing of dexamethasone administration during anesthesia induction affects patient outcomes after surgery. Dexamethasone is commonly used to reduce nausea and inflammation during and after surgery. However, it is not yet known if administering dexamethasone at different times during induction (before, during, or after specific anesthetic drugs) leads to better recovery and fewer postoperative complications.
Participants will be randomly assigned to one of three groups: one group will receive dexamethasone before fentanyl, another after the muscle relaxant, and a third group will not receive dexamethasone. This approach will help us understand if the timing of dexamethasone affects patient outcomes such as nausea, pain, and recovery quality. The study is triple-blinded, meaning that the participants, care providers, and investigators will not know which group the participants are in, to ensure unbiased results.
Adults aged 18 years or older
Scheduled for elective non cardiac surgery requiring general anesthesia
surgery last at least 90 minutes
scare of more than 5 cm Able to provide informed consent Eligible for dexamethasone administration as part of routine perioperative care
Known allergy or hypersensitivity to dexamethasone or related corticosteroids
History of uncontrolled diabetes mellitus or significant blood glucose management issues, as dexamethasone may affect glucose levels
Severe cardiovascular instability or hemodynamic issues contraindicating study participation
Patients receiving immunosuppressive therapy or with conditions affecting the immune system, as corticosteroids may alter immune responses
AABDI Mohammed
Lead sponsor
University Abdelmalek Essaadi faculty of medicine and pharmacy Tangier
Sponsor institution
University Hospital Center Mohammed VI Tangier, Morocco
Collaborator