Health Trials

Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients

ConditionsFrailtyEsmololMyocardial Injury
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age65-90
SponsorYongtao Sun

About this trial

This topic will focus on the following questions:

1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation. 2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.

Eligibility criteria

Qualifiers

Age ≥ 65 years;

ASA: ⅰ-ⅳ;

Modified frailty index (mFI) ≥ 0.21;

Patients undergoing non-cardiac surgery.

Disqualifiers

Refuse to participate;

Expected hospital stay <3 days;

Preoperative β-blocker therapy;

History of myocardial infarction or coronary artery disease;

Trial design

Treatments tested in this trial

  • Esmolol
  • Placebo Comparator: Placebo Comparator:normal saline(0.9%)

Treatment groups

2,000 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Yongtao Sun

Lead sponsor

Qianfoshan Hospital

Sponsor institution

Source ClinicalTrials.gov