ConditionUveitis
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-65
SponsorPeking Union Medical College Hospital
About this trial
This study is a multi-center randomized non-inferiority study that aims to observe the short-term (3 months) efficacy and safety of adalimumab plus medium-dose glucocorticosteroid (30mg/d prednisone or equivalent) with slow tapering for recurrent Behçet's uveitis (BU) attack compared with adalimumab plus high-dose glucocorticosteroid (60mg/d prednisone or equivalent) with slow tapering.
Eligibility criteria
Qualifiers
Behçet's disease (BD) patients fulfilling the International Criteria for Behçet's disease (ICBD) published in 2013 with recent recurrence of pan- or posterior uveitis
The patient should be on ≥10mg/d oral prednisone or equivalent
Disqualifiers
Previous treatment with TNFα inhibitors within 3 months
Pregnancy, breast feeding women
Malignancy
Heart failure
Trial design
Treatments tested in this trial
- Adalimumab plus different doses of oral glucocorticosteroid
Treatment groups
130 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov