Efficacy and Safety of Adalimumab Plus Medium Dose Oral Glucocorticosteroid for Refractory Behçet's Uveitis

ConditionUveitis
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-65
SponsorPeking Union Medical College Hospital

About this trial

This study is a multi-center randomized non-inferiority study that aims to observe the short-term (3 months) efficacy and safety of adalimumab plus medium-dose glucocorticosteroid (30mg/d prednisone or equivalent) with slow tapering for recurrent Behçet's uveitis (BU) attack compared with adalimumab plus high-dose glucocorticosteroid (60mg/d prednisone or equivalent) with slow tapering.

Eligibility criteria

Qualifiers

Behçet's disease (BD) patients fulfilling the International Criteria for Behçet's disease (ICBD) published in 2013 with recent recurrence of pan- or posterior uveitis

The patient should be on ≥10mg/d oral prednisone or equivalent

Disqualifiers

Previous treatment with TNFα inhibitors within 3 months

Pregnancy, breast feeding women

Malignancy

Heart failure

Trial design

Treatments tested in this trial

  • Adalimumab plus different doses of oral glucocorticosteroid

Treatment groups

130 Participants
are divided into 2 treatment groups

Locations

This trial has no locations