This study aims to evaluate the value of Shexiang Baoxin Pill (MUSKARDIA) in patients with acute myocardial infarction (AMI) through a prospective, multicenter, pragmatic randomized controlled real-world study. It seeks to validate its efficacy in reducing cardiovascular event risk during the peri-PCI period, as well as its effects on cardiac function, quality of life , and relevant biomarkers. Through this research, we expect to provide higher-quality evidence for the application of SBP in AMI patients undergoing PCI, thereby further optimizing comprehensive treatment strategies for AMI.
Aged 18 years or older, regardless of gender
In accordance with the 2023 ESC Guidelines for the Management of Acute Coronary Syndromes , meeting the diagnostic criteria for acute myocardial infarction, including typical chest pain lasting for ≥20 minutes, electrocardiographic manifestations of ST-segment elevation (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), and serum high-sensitivity troponin (hs-cTn) levels exceeding the 99th percentile of the upper reference limit at least once with dynamic changes
Presenting for treatment within <24 hours of symptom onset and scheduled to undergo PCI
The patient or their guardian has signed the informed consent form
Having contraindications to PCI treatment
Being allergic to Shexiang Baoxin Pills, unable to tolerate them, or having other conditions that prevent completion of the trial drug administration
Being pregnant, planning to become pregnant, or breastfeeding women
Having participated in other clinical studies within 3 months
Shanghai Hutchison Pharmaceuticals Limited
Lead sponsor
Shanghai Zhongshan Hospital
Collaborator
Huashan Hospital
Collaborator
Shanghai 10th People's Hospital
Collaborator
Shanghai 6th People's Hospital
Collaborator
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Collaborator
Shanghai East Hospital
Collaborator
Longhua Hospital
Collaborator
Second Affiliated Hospital of Soochow University
Collaborator
Affiliated Hospital of Jiangsu University
Collaborator
The First Affiliated Hospital with Nanjing Medical University
Collaborator
The First People's Hospital of Lianyungang
Collaborator
Huai'an First People's Hospital
Collaborator
Sir Run Run Shaw Hospital
Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborator
First Affiliated Hospital of Ningbo University
Collaborator
Shandong Provincial Hospital
Collaborator
Qianfoshan Hospital
Collaborator
Weihai Municipal Hospital
Collaborator
Weifang People's Hospital
Collaborator
Rizhao People's Hospital
Collaborator
The Affiliated Hospital of Qingdao University
Collaborator
Jining First People's Hospital
Collaborator
Linyi People's Hospital
Collaborator
Xiangya Hospital of Central South University
Collaborator
Second Xiangya Hospital of Central South University
Collaborator
Yueyang Central Hospital
Collaborator
The First Affiliated Hospital of University of South China
Collaborator
The Central Hospital of Shaoyang
Collaborator
The First People's Hospital of Changde City
Collaborator
Wuxi People's Hospital
Collaborator
Jinhua Central Hospital
Collaborator
The Third Affiliated Hospital of Wenzhou Medical University
Collaborator
Shuguang Hospital of Shanghai University of Traditional Chinese Medicine
Collaborator
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Collaborator
ZhuZhou Central Hospital
Collaborator
First People's Hospital of Chenzhou
Collaborator
People's Hospital of Quzhou
Collaborator
Xuzhou New Health Hospital
Collaborator
Taizhou Enze Medical Center Group
Collaborator
Beijing Chao Yang Hospital
Collaborator
Civil Aviation General Hospital
Collaborator
Xuanwu Hospital, Beijing
Collaborator
Beijing Friendship Hospital
Collaborator
Peking University People's Hospital
Collaborator
Beijing Electric Power Hospital
Collaborator
Renmin Hospital of Wuhan University
Collaborator
Wuhan No.1 Hospital
Collaborator
Jingzhou Central Hospital
Collaborator
The First Affiliated Hospital of Dalian Medical University
Collaborator
Ansteel Group General Hospital
Collaborator
General Hospital of Fuxin Mining Industry Group of Liaoning Health Industry Group
Collaborator
The First Affiliated Hospital of Zhengzhou University
Collaborator
Huaihe Hospital of Henan University
Collaborator
Zhoukou Central Hospital
Collaborator
The First Affiliated Hospital of Henan University of Science and Technology
Collaborator
First Affiliated Hospital of Nanyang Medical College
Collaborator
Jiaozuo Second People's Hospital
Collaborator
Anyang Area Hospital of Puyang City
Collaborator
Shijiazhuang People's Hospital
Collaborator
Cangzhou Central Hospital
Collaborator
The First Hospital of Hebei Medical University
Collaborator
Handan Central Hospital
Collaborator
The People's Hospital of Langfang City
Collaborator
Xingtai Central Hospital
Collaborator
North China University of Science and Technology
Collaborator
The First Affiliated Hospital of Anhui Medical University
Collaborator
the First Hospital of Anhui University of Science and Technology
Collaborator
Chaohu Hospital of Anhui Medical University
Collaborator
Tongling People's Hospital
Collaborator
Huang Shan People's Hospital
Collaborator
Huaibei Miners General Hospital
Collaborator
The Second Affiliated Hospital of Fujian Medical University
Collaborator
Changzhi Medical College
Collaborator
LinFen People's Hospital
Collaborator
Shanxi Cardiovascular Hospital
Collaborator
Dazhou First People's Hospital
Collaborator
The Affiliated Hospital Of Southwest Medical University
Collaborator
The Third Affiliated Hospital of Guangzhou Medical University
Collaborator
The First Affiliated Hospital of Guangdong Pharmaceutical University
Collaborator
Yangchun People's Hospital
Collaborator
Shaoguan People's Hospital
Collaborator
Guilin People's Hospital
Collaborator
The First Affiliated Hospital of Nanchang University
Collaborator
Ji'an Central People's Hospital
Collaborator
Jiangxi Provincial People's Hopital
Collaborator
People's Hospital of Chongqing
Collaborator
Ankang Central Hospital
Collaborator
Xiangyang Central Hospital
Collaborator
Tianjin Third Central Hospital
Collaborator
General Hospital of Ningxia Medical University
Collaborator
The Second Affiliated Hospital of Hainan Medical University
Collaborator
Lanzhou University Second Hospital
Collaborator
Jilin Province People's Hospital
Collaborator
Inner Mongolia Autonomous Region People's Hospital
Collaborator
Yan'an Affiliated Hospital of Kunming Medical University
Collaborator
The People's Hospital of Jizhou District, Tianjin
Collaborator
The Southwest Hospital of Army Medical University
Collaborator
The First People's Hospital of Nanning
Collaborator
The People' s Hospital of Jiangmen
Collaborator
The second People's Hospital of Guiyang
Collaborator
The Third People's Hospital of Chengdu
Collaborator
The Tirst People's Hospital of Mianyang
Collaborator
First Affiliated Hospital of Fujian Medical University
Collaborator
The First People's Hospital of Chu Zhou
Collaborator
Xuancheng People's Hospital
Collaborator