About this trial
The main objective of this study is to compare the efficacy and safety of the triple combination therapy of Met/SGLT-2i/GLP-1RA or other oral antidiabetic drugs in patients with type 2 diabetes exhibiting poor glycemic control.
Eligibility criteria
Qualifiers
Meet the diagnostic criteria for type 2 diabetes (refer to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 edition)); -Age: 18-75 years old (including the threshold), male or female;
Body mass index (BMI) ≥20kg/m² ;
Patients who took 1000mg or more of metformin in combination with or without another oral hypoglycemic agent (except SGLT-2i and oral GLP-1RA) for at least 8 weeks before screening and had poor blood glucose control (centralized detection of HBA1C >=7.5% and<=11.0%);
Volunteer to participate in this study and sign informed consent.
Disqualifiers
Patients with type 1 diabetes or other special types of diabetes;
Patients with acute complications of ketoacidosis/hyperglycemic hyperosmolar state/lactic acidosis within 6 months before screening
Those who have used GLP-1RA and SGLT-2i drugs within 12 weeks before screening, or have used GLP-1RA and SGLT-2i drugs in the past and discontinued due to poor efficacy
Those who received insulin treatment within the previous week
Trial design
Treatments tested in this trial
- Metformin
- Triple Therapy of Other Oral Antidiabetic Drugs
- ganagliflozin
- liraglutide