The study aimed to compare the efficacy and safety of dual and quadruple regimens with different durations (7-day, 10-day, 14-day) for the eradication of Helicobacter pylori. Subjects were randomized to receive the intervention and were reviewed by 13C-urea breath test after 6 weeks. The eradication rates, adverse reaction rates and patient adherence were calculated.
Patients aged 18-70 years old
Patients with H.pylori infection (13C/14C-urea breath test)
Patients without previous treatment for H. pylori eradication
Patients with serious underlying diseases, such as liver insufficiency (Aspartate aminotransferase or alanine aminotransferase greater than the normal value), renal insufficiency (Cr≥2.0mg/dL or glomerular filtration rate <50 ml/min), immunosuppression, malignant tumors, Coronary heart disease or coronary artery stenosis ≥75%
Patients with active gastrointestinal bleeding
Patients with a history of upper gastrointestinal surgery
Patients allergic to treatment drugs
Shandong University
Lead sponsor
Zibo Maternal and Child Health Hospital
Collaborator
Zaozhuang Municipal Hospital
Collaborator
Feicheng Municipal People's Hospital
Collaborator
Shandong University of Traditional Chinese Medicine
Collaborator
The People's Hospital of Jimo.Qingdao
Collaborator
Dezhou Hospital Qilu Hospital of Shandong University
Collaborator