Pregnant women with HBeAg-positive viral hepatitis b or high viral load will receive Tenofovir disoproxil fumarate (TDF) from the 28th week of amenorrhoea until 6 weeks after delivery. Their newborns will receive the hepatitis B vaccine, starting with one dose at birth and followed by three booster doses, according to the Expanded Programme on Immunisation.
The investigators hypothesise that a short course of TDF could greatly reduce the risk of HBV MTCT in pregnant women at high risk of MTCT (HBeAg positive or with high viral load).
Pregnant women with a term of less than 24 weeks of amenorrhea;
HBsAg positive ;
HBeAg positive or HBeAg negative with a high viral load ( > 200 000 UI/ml) ;
16 years old or more on the inclusion day ;
HIV co-infection;
Women treated for HBV;
Creatinine clearance <30 ml / min;
Suspicion of poor monitoring of children's vaccination schedule for HBV (vaccination at birth + boosters);