Etonogestrel (ENG) Implant Insertion for Emergency Contraception With Oral Levonorgestrel (LNG) vs Placebo

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age18-35
SponsorLori Gawron

About this trial

Intrauterine devices (IUDs) are highly effective to prevent pregnancy when used for emergency contraception (following unprotected intercourse in the last 3 days), but data are lacking for people who desire an etonogestrel (ENG) contraceptive implant in this situation. This proposal will identify the most effective way to start an implant for emergency contraception using a randomized controlled trial comparing pregnancy risk between those receiving the implant vs. the implant plus oral emergency contraception (EC). Data from this project will inform clinical practice and add another option, the implant, for those desiring a long acting, highly effective contraceptive method when they present for emergency contraception.

Eligibility criteria

Qualifiers

Between 18-35 years old

Unprotected intercourse within 72 hours

Biologically capable of pregnancy (intact uterus without prior sterilization surgery

Fluent in English and/or Spanish

Disqualifiers

Current pregnancy (+urine pregnancy test in clinic)

Breastfeeding

Contraindication to ENG or LNG based on CDC MEC/SPR

Sterilization, hysterectomy, or has an IUD or contraceptive implant in place

Trial design

Treatments tested in this trial

  • Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg
  • Etonogestrel implant with oral placebo

Treatment groups

790 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Lori Gawron

Lead sponsor

University of Utah

Sponsor institution

Planned Parenthood Association of Utah

Collaborator