Fluid Challenge and Plasma Volume, During Surgery
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-85
SponsorJoachim Zdolsek
About this trial
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.
Eligibility criteria
Qualifiers
Written consent to participate in the study
For women: relevant contraceptive, menopausal or a negative pregnancy test.
ASA category I to III
Laparoscopic abdominal surgery, with a duration of at least 90 minutes.
Disqualifiers
Patients with known cardiac failure
<18 or >85 years
known allergy to albumin
extracellular hyperhydration or hypervolemia
Trial design
Treatments tested in this trial
- acetated Ringers
- albumin 5%
- albumin 20%
Treatment groups
60 Participants
are divided into 3 treatment groupsSponsors and collaborators
Joachim Zdolsek
Lead sponsor
University Hospital, Linkoeping
Sponsor institution
Source ClinicalTrials.gov