Flush, Lyse, Operate
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorDartmouth-Hitchcock Medical Center
About this trial
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is:
What is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery?
Participants will:
* Receive receive saline into their pleural space through an existing chest tube * If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube * If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.
Eligibility criteria
Qualifiers
Age 18+
Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy
Are able to personally or have a designated medical decision maker provide consent
Disqualifiers
Age < 18 years
Have received any intrapleural medications prior to enrolment via current chest tube
Anticoagulation
Active hemorrhage
Trial design
Treatments tested in this trial
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov