Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
ConditionAsthma
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorMontefiore Medical Center
About this trial
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
Eligibility criteria
Qualifiers
Adults ≥18 years old presenting to the ED with an asthma exacerbation
Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
Discharged from the ED with a primary diagnosis of asthma exacerbation
Initiated systemic corticosteroids during the ED visit
Disqualifiers
Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
History of severe adverse reactions to corticosteroids
Heart failure and uncontrolled diabetes (glucose >300mg/dL in the ED)
Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
Trial design
Treatments tested in this trial
- Dexamethasone 16mg IM
- Prednisone 60mg PO
Treatment groups
182 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov