Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age19+
SponsorSeoul National University Hospital

About this trial

This trial aims to compare two intraoperative fluids, namely hydroxyethyl starch (HES) and balanced crystalloids in terms of major adverse kidney events after cardiac surgery. Indications for the study fluids administarion include preload augmentation and intravascular volume replacement during cardiac surgery.

Eligibility criteria

Qualifiers

Patients aged 19 years or older scheduled for coronary artery bypass grafting (CABG), heart valve surgery, and/or thoracic aortic surgery

Disqualifiers

Emergency surgery;

Planned implantation of a durable left ventricular assist device;

History of starch allergy or hypersensitivity;

History of kidney transplantation;

Trial design

Treatments tested in this trial

  • Volulyte® (6% HES 130/0.4 in balanced solution)
  • Crystalloid solutions

Treatment groups

1,292 Participants
are divided into 2 treatment groups