Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorPeking University First Hospital
About this trial
For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.
Eligibility criteria
Qualifiers
Aged 18 years or over;
Scheduled to undergo surgery under general anesthesia, with an expected surgical duration of at least 1 hour;
Required patient-controlled intravenous analgesia after surgery.
Disqualifiers
Unable to communicate preoperatively due to visual, auditory, or verbal barriers or other reasons;
Severe bradycardia (heart rate <50 bpm), sick sinus syndrome, or grade 2 or higher atrioventricular block without pacemaker;
History of hyperthyroidism or pheochromocytoma;
History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;
Trial design
Treatments tested in this trial
- Dexmedetomidine
- Esketamine
- Dexmedetomidine-esketamine
- Placebo
Treatment groups
316 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov