Individual Cerebral Hemodynamic Oxygenation Relationships
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
AgeUp to 1
SponsorMatthew Borzage
About this trial
This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All eligible subjects will be asked to provide informed consent before participating in the study.
Eligibility criteria
Qualifiers
Patients who are scheduled for a clinically indicated MRI at the sponsor institution.
Patients who are able to tolerate an MRI.
Patients who require clinical anesthesia for their MRI.
Patients with conditions not believed to alter oxygen metabolism or blood flow in the brain, including but not limited to patients with orthopedic indications, undescended testicles, hernia repairs, term equivalent age scans.
Disqualifiers
Patients with an MRI-incompatible device or implant (e.g. pacemakers, stents)
Preterm infants less than 25 weeks postmenstrual age (PMA) at the time of the scan.
Patients who are clinically too unstable to extend their MRI by up-to 10 minutes.
Patients who do not require clinical anesthesia.
Trial design
Treatments tested in this trial
- Propofol or Sevoflurane
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Matthew Borzage
Lead sponsor
Children's Hospital Los Angeles
Sponsor institution
Source ClinicalTrials.gov