Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorEmory University

About this trial

Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints.

The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy.

Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed.

Eligibility criteria

Qualifiers

Age 18 or older,

symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist who have not undergone prior surgical treatment for their condition.

Diagnoses may include trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal (CMC) joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis.

Disqualifiers

Patients under the age of 18,

Patients who have undergone prior triamcinolone or ketorolac injections within the past 6 months,

Patients who have undergone prior surgical treatment for their hand condition,

Patients with allergy or contraindication to triamcinolone or ketorolac injection,

Trial design

Treatments tested in this trial

  • Triamcinolone injection to the shoulder, elbow, wrist, or hand
  • Ketorolac injection to the shoulder, elbow, wrist, or hand

Treatment groups

160 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Emory University

Lead sponsor

American Association for Hand Surgery: AAHS

Collaborator