Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies

ConditionBreast Cancer
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUnited States Naval Medical Center, Portsmouth

About this trial

Perform a comparison of effective pain relief duration between liposomal bupivacaine and dexmedetomidine when added to bupivacaine in a block for mastectomy for cancer surgery. The erector spinae plane block is a well-established block that is utilized for post operative pain control for procedures performed on the soft tissue of the chest and chest wall as well as intrathoracic procedures. The goal is comparison of the effective duration of both study groups to determine if there is a significant difference in time and amount of post operative opioids required which admitted to hospital.

Eligibility criteria

Qualifiers

Patients requiring any variation of mastectomy with or without axillary lymph node dissection.

Patient agrees to a peripheral nerve block.

Patient agrees to be a study participant.

APS team believes a peripheral nerve block would be appropriate for the patient after reviewing medical/surgical history.

Disqualifiers

Patient declines a peripheral nerve block.

Patient declines to be a study participant.

APS team believes a peripheral nerve block is not clinically indicated.

Surgeon does not want a peripheral nerve block.

Trial design

Treatments tested in this trial

  • Dexmedetomidine
  • Liposomal bupivacaine

Treatment groups

200 Participants
are divided into 2 treatment groups