Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorBach Mai Hospital
About this trial
This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis. Adults with secondary peritonitis who are scheduled for emergency surgery and have stable blood pressure after initial resuscitation will be randomly assigned to receive either norepinephrine or placebo (normal saline) during induction of anesthesia. The main outcome is the cumulative time spent with mean arterial pressure (MAP) below 65 mmHg from the start of propofol administration to 10 minutes after endotracheal intubation. The study will also evaluate rescue vasopressor use, heart rate changes, drug-related adverse events, and selected early postoperative outcomes.
Eligibility criteria
Qualifiers
Adults aged 18 years or older.
Secondary peritonitis requiring emergency surgery under general anesthesia with endotracheal intubation.
Planned induction with fentanyl, propofol, and rocuronium according to the study protocol.
Hemodynamically stabilized after initial resuscitation, with MAP at least 65 mmHg and no ongoing vasopressor infusion before induction.
Disqualifiers
Allergy or contraindication to norepinephrine, propofol, fentanyl, or rocuronium.
Severe cardiovascular disease likely to confound hemodynamic assessment, including decompensated heart failure, acute coronary syndrome, severe arrhythmia, severe valvular disease, or major cardiomyopathy.
Ongoing vasopressor therapy before induction.
Shock before surgery, including hypovolemic, septic, or cardiogenic shock.
Trial design
Treatments tested in this trial
- Norepinephrine (0.05 μg/kg/min)
- Placebo
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov