Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorWake Forest University Health Sciences

About this trial

The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms.

Eligibility criteria

Qualifiers

Age ≥18 years

Aneurysmal subarachnoid hemorrhage with Hunt and Hess score 3 or less

Patient or legal authorized representative available to sign the informed consent form

Pre-morbid modified Rankin scale of 0 or 1.

Disqualifiers

Pregnant females

Subarachnoid hemorrhage (SAH) with hunt and hess scale of >3

SAH due to etiology other than aneurysmal rupture

Any contraindications in patients receiving calcium channel antagonists like hypersensitivity to dihydropyridines

Trial design

Treatments tested in this trial

  • Normal Saline
  • Nicardipine

Treatment groups

214 Participants
are divided into 2 treatment groups