This is an investigator-initiated two-center study. The goal of this study is to investigate the feasibility, safety and efficacy outcomes of a seamless transition from mavacamten to aficamten in patients with obstructive hypertrophic cardiomyopathy (oHCM).
Documented history of oHCM with documented resting and/or Valsalva LVOT obstruction ≥ 50 mmHg who are currently receiving mavacamten commercially.
Echo-derived LVEF ≥55% on mavacamten at the time of enrollment.
Patient willing to consent for the study and undergo the study procedures.
Severe aortic stenosis or sub-aortic obstruction
Known infiltrative or storage disorder causing cardiac hypertrophy that mimics HCM (eg, Noonan syndrome, Fabry disease, amyloidosis).
History of LVEF <30%.
Paroxysmal atrial fibrillation (AF) with documented episode within 3 months.
Oregon Health and Science University
Lead sponsor
Saint Lukes Hospital Mid America Heart Institute
Collaborator
Cytokinetics
Collaborator