About this trial
The goal of this clinical trial is to compare participants treated with latanoprost to those treated with Rocklatan (netarsudil/latanoprost) to determine whether the addition of netarsudil results in greater improvements in episcleral venous blood flow in adults with glaucoma or ocular hypertension. Episcleral venous blood flow will be measured using erythrocyte-mediated angiography (EMA) and laser speckle contrast imaging (LSCI).
The main questions this study aims to answer are:
* Does Rocklatan produce greater increases in episcleral venous blood flow than latanoprost alone? * Can EMA and LSCI reliably detect changes in episcleral venous blood flow following treatment with these medications?
Participants will:
* Be randomized to receive either latanoprost or Rocklatan * Undergo imaging of the episcleral veins using EMA and LSCI before, during, and after treatment, and * Complete study visits that include standard ophthalmic examinations and intraocular pressure measurements.
Hypothesis: The investigators hypothesize that latanoprost, which primarily increases uveoscleral outflow, will not significantly affect the distal episcleral circulation. In contrast, Rocklatan, through its netarsudil component, is expected to produce measurable increases in episcleral venous flow.
Eligibility criteria
Qualifiers
Patients are at least 18 years of age.
Patients must have ocular hypertension or be a glaucoma suspect.
Patient must not have used any IOP-lowering medication (topical or systemic) within the past 6 months
Patients must have open angles on gonioscopy.
Disqualifiers
None
Trial design
Treatments tested in this trial
- Rocklatan (Netarsudil 0.02%/ latanoprost 0.005)
- Latanoprost (0.005%)
Treatment groups
Sponsors and collaborators
University of Maryland, Baltimore
Lead sponsor
Alcon Research
Collaborator