Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever
ConditionEnteric Fever
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age1-70
SponsorIndus Hospital and Health Network
About this trial
1. Primary Objective:
o To evaluate the efficacy of intravenous azithromycin compared with meropenem in the treatment of extensively drug-resistant (XDR) enteric fever. 2. Secondary Objectives:
* To evaluate the fever defervescence and Salmonella Typhi eradication * To evaluate the cost-effectiveness of intravenous azithromycin versus meropenem in treating XDR enteric fever. 3. Exploratory Objectives:
* To evaluate the drug resistance against intravenous azithromycin versus in treating XDR enteric fever.
Eligibility criteria
Qualifiers
Participants will enrolled on following criteria
Voluntarily sign the written informed consent
Patient's of age 1-70 years with clinically suspected on physician decision or XDR enteric fever confirmed by blood culture and sensitivity tests.
Married females with negative pregnancy test.
Disqualifiers
Participants will excluded on following criteria
Pregnant, lactating women or women of childbearing age with positive pregnancy test at baseline.
Patients with known hypersensitivity (skin rashes, anaphylaxis) to azithromycin, meropenem, or any other macrolide or carbapenem antibiotics.
Blood culture and sensitivity tests reported positive culture with MDR S. typhi (non-susceptibility to at least one agent in three or more antimicrobial categories,) o
Trial design
Treatments tested in this trial
- Azithromycin
- Meropenem Injection
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov