Multiple Electrolytes Injection (II) and Normal Saline on Hyperchloremia in Severe Hemorrhagic Stroke
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorCapital Medical University
About this trial
Normal saline (0.9% sodium chloride), a classical crystalloid solution, is widely used to maintain fluid balance, volume resuscitation and dilute drugs during clinical practice. However, the chloride concentration of normal saline (154mmol/L) is much higher than human plasma, and a large amount of infusion may lead to iatrogenic hyperchloremia in ICU patients. In contrast, the concentrations of Multiple electrolytes II is more similar to those of plasma and is considered to be a better fluid choice than normal saline.
Eligibility criteria
Qualifiers
Patients with a diagnosis of hemorrhagic stroke (cerebral hemorrhage, intraventricular hemorrhage, or subarachnoid hemorrhage confirmed by CT or MRI, except for subdural or extradural hemorrhage caused by tramma)
Patients requiring fluid therapy
Patients over 18 years old
Disqualifiers
Hemorrhage onset more than 72hours
Preexisting hyperchloremia(blood chloride > 110mmol/L)
Presence of hypothalamic disease or cerebral salt wasting syndrome
Patients who can eat by themselves
Trial design
Treatments tested in this trial
- Multiple Electrolyte
- Normal Saline
Treatment groups
342 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov