Nanozymes in Endodontics
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Pennsylvania
About this trial
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment. Building on prior protocols that demonstrated ferumoxytol nanozymes antimicrobial activity as a root canal irrigant, ferumoxytol solution will be applied topically, assessment of clinical and radiographical findings will determine its potential as a novel disinfection and its long-term outcome.
Eligibility criteria
Qualifiers
Patients willing to participate in the study.
Patients are 18 years or above.
Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II).
Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and
Disqualifiers
Self-reported pregnancy.
Patients requiring antibiotic premedication prior to dental treatment.
Patients with multiple drug allergies.
Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products.
Trial design
Treatments tested in this trial
- Nanozyme treatment
- Control (Standard treatment)
Treatment groups
72 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov