Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
ConditionKnee Osteoarthritis
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age45+
SponsorUniversidade do Porto
About this trial
This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic). Patients will be selected with the aim of matching for important confounders (sex and age) the grade of knee OA will be restricted to advance stages.
Eligibility criteria
Qualifiers
Adult individuals with unilateral or bilateral symptomatic knee OA diagnosis according to the American College of Rheumatology
with symptoms for more than 3 months
confirmed with radiologic diagnosis (Kellgren-Lawrence grades III or IV).
Patients must be able to walk with a painful knee.
Disqualifiers
previous history of knee surgery
systemic autoimmune or rheumatic disease
platelet diseases
use of NSAIDs 3 days prior the injections
Trial design
Treatments tested in this trial
- Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov