Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorCharles University, Czech Republic
About this trial
HyPerMICROBE is a single-centre, controlled, randomised, prospective, superiority clinical trial to compare the efficacy of daily oral care with 3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine digluconate) on the cumulative incidence of lower respiratory tract microbial colonisation in mechanically ventilated adult critically ill patients.
Eligibility criteria
Qualifiers
Age ≥18 years
In-patient of ICU and expected to stay > 5 days
Mechanical ventilation or imminent need of it; predicted length of mechanical ventilation (MV) ≥ 72h
Clinical Pulmonary Infection score (CPIS) less than 6 at the baseline
Disqualifiers
ATB therapy of respiratory infection on admission
Suspected pulmonary infection on admission and in the first 48h of mechanical ventilation
Pregnancy
Oral ulcers or injuries
Trial design
Treatments tested in this trial
- Oroxid®
- Chlorhexidine mouthwash
Treatment groups
160 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov